2013年8月10日星期六

维生素 D 与自身免疫性疾病关系的研究


“流行病学证据表明维生素D缺乏和自身免疫性疾病如红斑狼疮,风湿性关节炎,一型糖尿病及多发性硬化症的发病率的增高有显著相关性。”

Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases, such as SLE, RA, T1DM, and MS. Arthritis Research & Therapy. 10:123, 2008


“日照不足增加多发性硬化症的发病率”

“A limited exposure to sunlight and other correlates of vitamin D exposure has been associated constantly with an increased risk of MS.”  Lancet Neurology, 9(6):599-612, 2010


“许多自身免疫性疾病在日照不足的国家发病率增高”

Many autoimmune diseases such as type 1 diabetes mellitus or multiple sclerosis (MS) are more frequent in countries with less sunshine.” Nat Clin Pract Rheumatol. 5:99-105, 2009


“人群补充维生素D对一些自身免疫性疾病有预防作用”

Supplementation (of vitamin D) in human may be preventive in a number of autoimmune disorders.” Ann Rheum Dis. 66:1137-42, 2007



“维生素D3抑制免疫杀伤T细胞的分化和游走从而防止EAE形成”

Vitamin D3 inhibits the differentiation and migration of Th17 cells to protect against EAE.”  PLoSone, 5(9): e12925, 2010


维生素D的免疫调节功能

专家推荐对下列五类疾病补充维生素D

  • 骨折
  • 摔倒 (falls)
  • 心血管疾病
  • 自身免疫性疾病
  • 癌症

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